2. Academic Validation
  3. Interferon-omega: Current status in clinical applications

Interferon-omega: Current status in clinical applications

  • Int Immunopharmacol. 2017 Nov;52:253-260. doi: 10.1016/j.intimp.2017.08.028.
Shi-Fang Li 1,  Fu-Rong Zhao 2,  Jun-Jun Shao 1,  Yin-Li Xie 1,  Hui-Yun Chang 3,  Yong-Guang Zhang 1
Affiliations

Affiliations

  • 1 State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, Gansu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu Province 225009, China.
  • 2 State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, Gansu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu Province 225009, China.. Electronic address: zhaofurong@caas.cn.
  • 3 State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, Gansu, China.; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu Province 225009, China.. Electronic address: changhuiyun@caas.cn.
PMID: 28957693 DOI: 10.1016/j.intimp.2017.08.028
Abstract

Since 1985, interferon (IFN)-ω, a type I IFN, has been identified in many Animals, but not canines and mice. It has been demonstrated to have Antiviral, anti-proliferation, and antitumor activities that are similar to those of IFN-α. To date, IFN-ω has been explored as a treatment option for some diseases or viral infections in humans and other Animals. Studies have revealed that human IFN-ω displays antitumor activities in some models of human Cancer cells and that it can be used to diagnose some diseases. While recombinant feline IFN-ω has been licensed in several countries for treating canine parvovirus, feline leukemia virus, and feline immunodeficiency virus infections, it also exhibits a certain efficacy when used to treat other viral infections or diseases. This review examines the known biological activity of IFN-ω and its clinical applications. We expect that the information provided in this review will stimulate further studies of IFN-ω as a therapeutic agent.

Keywords

Application; Biological activity; Interferon omega; Type I IFN.

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