2. Academic Validation
  3. Blockade of excitatory synaptic transmission by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in the hippocampus in vitro

Blockade of excitatory synaptic transmission by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in the hippocampus in vitro

  • Neurosci Lett. 1988 Sep 23;92(1):64-8. doi: 10.1016/0304-3940(88)90743-4.
R S Neuman 1,  Y Ben-Ari,  M Gho,  E Cherubini
Affiliations

Affiliation

  • 1 INSERM U29, Hôpital de Port-Royal, Paris, France.
PMID: 2903471 DOI: 10.1016/0304-3940(88)90743-4
Abstract

Superfusion of hippocampal slices with 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 2-5 microM) reversibly blocked the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow gamma-aminobutyric acid (GABA)-mediated inhibition. Membrane potential, input resistance and spike accommodation were not altered. Inward currents induced by quisqualate were reduced to a greater extent by CNQX than those induced by kainate or N-methyl-D-aspartate. We suggest that CNQX may be a useful antagonist to study excitatory amino acid-mediated synaptic transmission.

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