2. Academic Validation
  3. Cytotoxic Cardiac Glycoside Constituents of Vallaris glabra Leaves

Cytotoxic Cardiac Glycoside Constituents of Vallaris glabra Leaves

  • J Nat Prod. 2017 Nov 22;80(11):2987-2996. doi: 10.1021/acs.jnatprod.7b00554.
Sudarat Kruakaew 1,  Chonticha Seeka 1,  Thitima Lhinhatrakool 2,  Sanit Thongnest 3,  Jantana Yahuafai 4,  Suratsawadee Piyaviriyakul 4,  Pongpun Siripong 4,  Somyote Sutthivaiyakit 1
Affiliations

Affiliations

  • 1 Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University , Hua Mark, Bangkapi, Bangkok 10240, Thailand.
  • 2 College of Oriental Medicine, Rangsit University , Muang Ake, Pathumthani 12000, Thailand.
  • 3 Chulabhorn Research Institute , Kamphang Phet 6 Road, Bangkok 10210, Thailand.
  • 4 Natural Products and Integrative Medicine Research Section, Research Division, National Cancer Institute , Rama VI Road, Bangkok 10400, Thailand.
PMID: 29072457 DOI: 10.1021/acs.jnatprod.7b00554
Abstract

Thirteen cardenolide glycosides (1-13) were isolated from the CH2Cl2 and MeOH extracts of Vallaris glabra leaves. The structures of the new compounds (2-13) were identified by spectroscopic methods, with the absolute configurations of the sugar moieties determined by acid hydrolysis. All compounds were evaluated for their cytotoxic activity against human cervix adenocarcinoma, lung carcinoma, and colorectal adenocarcinoma cell lines. The two most potent compounds [2'-O-acetylacoschimperoside P (1) and oleandrigenin-3-O-α-l-2'-O-acetylvallaropyranoside (2)] exhibited IC50 values in the range of 0.03-0.07 μM.

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