2. Academic Validation
  3. Inducing Secondary Metabolite Production by Combined Culture of Talaromyces aculeatus and Penicillium variabile

Inducing Secondary Metabolite Production by Combined Culture of Talaromyces aculeatus and Penicillium variabile

  • J Nat Prod. 2017 Dec 22;80(12):3167-3171. doi: 10.1021/acs.jnatprod.7b00417.
Zhenzhen Zhang 1,  Xueqian He 1,  Guojian Zhang 1 2,  Qian Che 1,  Tianjiao Zhu 1,  Qianqun Gu 1,  Dehai Li 1 2
Affiliations

Affiliations

  • 1 Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, P.R. China.
  • 2 Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology , Qingdao 266237, P.R. China.
PMID: 29144133 DOI: 10.1021/acs.jnatprod.7b00417
Abstract

Four new polyketides, penitalarins A-C (1-3) and nafuredin B (4), together with the known biogenetically related nafuredin A (5) were isolated from a mixed culture of a deep-sea-derived fungus Talaromyces aculeatus and a mangrove-derived fungus Penicillium variabile. Liquid chromatography/mass spectrometry analysis showed that none of compounds 1-5 was produced by either of the two fungi when cultured alone under the same condition. The structures of 1-4, including absolute configurations, were deduced based on the interpretation of MS, NMR data, and time-dependent density functional theory calculations of specific electronic circular dichroism spectra. Compounds 1-3 possess a 3,6-dioxabicyclo[3.1.0]hexane ring, and 4 showed cytotoxicity with IC50 values ranging from 1.2 to 9.8 μM against a panel of human Cancer cell lines.

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