2. Academic Validation
  3. The antimicrobial peptide HS-1 inhibits dengue virus infection

The antimicrobial peptide HS-1 inhibits dengue virus infection

  • Virology. 2018 Jan 15:514:79-87. doi: 10.1016/j.virol.2017.11.009.
Juliana M C Monteiro 1,  Michelle D Oliveira 1,  Roberto S Dias 1,  Lorena Nacif-Marçal 2,  Renato N Feio 3,  Sukarno O Ferreira 4,  Leandro L Oliveira 2,  Cynthia C Silva 5,  Sérgio O Paula 6
Affiliations

Affiliations

  • 1 Laboratory of Molecular Immunovirology, General Biology Department, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.
  • 2 Laboratory of Immunochemistry and Glicobiology, General Biology Department, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.
  • 3 Joao Moojen Museum of Zoology, Animal Biology Department, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.
  • 4 Laboratory of Nanoscopy, Physics Department, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.
  • 5 Laboratory of Microbiology, Microbiology Department, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.
  • 6 Laboratory of Molecular Immunovirology, General Biology Department, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil. Electronic address: depaula@ufv.br.
PMID: 29153860 DOI: 10.1016/j.virol.2017.11.009
Abstract

Dengue virus (DENV) is an arbovirus that belongs to the Flaviviridae family. Studies reveal that Peptides secreted by amphibians have many functions, such as Antiviral and antimicrobial activities. As there is no Antiviral drug effective against the DENV, the Antiviral activity of a synthetic peptide called HS-1, derived from the secretion of the anuran Hypsiboas semilineatus, has been evaluated. The assays of neutralization in the Vero cells show a complete inhibition of Infection of the serotypes 2 and 3. Furthermore, the direct action of Peptides on the viral particle can be observed through atomic force microscopy. In vivo tests display 80% protection against the dengue-2 virus due to the presence of HS-1, which reveals its potential as an Antiviral against the DENV.

Keywords

Antimicrobial; Dengue Virus; Infection; Peptide HS-1.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-P5622
    Antimicrobial Peptides