Characteristic α-Acid Derivatives from Humulus lupulus with Antineuroinflammatory Activities

J Nat Prod. 2017 Dec 22;80(12):3081-3092. doi: 10.1021/acs.jnatprod.6b00921.

Jiayuan Li ¹, Ning Li ¹, Xuezheng Li ², Gang Chen ¹, Cungang Wang ¹, Bin Lin ³, Yue Hou ⁴

Affiliations

1 School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education , Wenhua Road 103, Shenyang 110016, People's Republic of China.
2 Department of Pharmacy, Affiliated Hospital of Yanbian University , Yanji 133000, People's Republic of China.
3 School of Pharmaceutical Engineering, Shenyang Pharmaceutical University , Shenyang 110016, People's Republic of China.
4 College of Life and Health Sciences, Department of Biochemistry and Molecular Biology, Northeastern University , Shenyang 110819, People's Republic of China.

PMID: 29154541 DOI: 10.1021/acs.jnatprod.6b00921

Abstract

Twenty compounds, including 14 new α-acid derivatives, a new chromone, and five known compounds, were identified from the pistillate inflorescence of Humulus lupulus (hops), and their structures were elucidated via physical data analysis. The absolute configurations of new α-acid derivatives 1-11b were determined by comparing their computed and experimental electronic circular dichroism spectra using TDDFT and NMR spectroscopic data. A putative biosynthetic pathway for the identified components was deduced. Their antineuroinflammatory effects were assayed systematically, and their structure-activity relationships are discussed briefly. Among the identified compounds, compound 14 displayed moderate inhibitory effects against nitric oxide production with an IC₅₀ value of 7.92 μM.

Name
Email *

	Sorry, but the email address you supplied was invalid.