2. Academic Validation
  3. Antiplasmodial alkaloids from bulbs of Amaryllis belladonna Steud

Antiplasmodial alkaloids from bulbs of Amaryllis belladonna Steud

  • Bioorg Med Chem Lett. 2018 Jan 1;28(1):40-42. doi: 10.1016/j.bmcl.2017.11.021.
Namki Cho 1,  Yongle Du 1,  Ana Lisa Valenciano 2,  Maria L Fernández-Murga 3,  Michael Goetz 4,  Jason Clement 4,  Maria B Cassera 2,  David G I Kingston 5
Affiliations

Affiliations

  • 1 Department of Chemistry and Virginia Tech Center for Drug Discovery, M/C 0212, Virginia Tech, Blacksburg, VA 24061, United States.
  • 2 Department of Biochemistry and Molecular Biology, and Center for Tropical and Emerging Global Diseases (CTEGD), University of Georgia, Athens, GA 30602, United States.
  • 3 Department of Biochemistry, M/C 0308, Virginia Tech, Blacksburg, VA 24061, United States.
  • 4 Natural Products Discovery Institute, 3805 Old Easton Road, Doylestown, PA 18902, United States.
  • 5 Department of Chemistry and Virginia Tech Center for Drug Discovery, M/C 0212, Virginia Tech, Blacksburg, VA 24061, United States. Electronic address: dkingston@vt.edu.
PMID: 29162457 DOI: 10.1016/j.bmcl.2017.11.021
Abstract

A bioassay-guided fractionation and chemical investigation of Amaryllis belladonna Steud. bulbs resulted in the isolation and identification of the new crinane alkaloid 1,4-dihydroxy-3-methoxy powellan (1), along with the 3 known crinane Alkaloids 2-4 and the two lycorane Alkaloids 5-6. The structures were elucidated by interpretation of combined HR-ESIMS, CD and 2D NMR spectroscopic data. Among these isolated compounds the lycorane-type alkaloid acetylcaranine (5) exhibited strong antiplasmodial activity, while compounds 3 and 4 were moderately active, and compounds 1 and 6 were inactive.

Keywords

Amaryllis belladonna; Antiplasmodial; Bioassay-guided; Crinane; Lycorine.

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