2. Academic Validation
  3. Prenylated flavonoids and dihydrophenanthrenes from the leaves of Epimedium brevicornu and their cytotoxicity against HepG2 cells

Prenylated flavonoids and dihydrophenanthrenes from the leaves of Epimedium brevicornu and their cytotoxicity against HepG2 cells

  • Nat Prod Res. 2018 Oct;32(19):2253-2259. doi: 10.1080/14786419.2017.1405410.
Xu Pang 1 2,  Shuang-Shuang Yin 1,  Hai-Yang Yu 1 2,  Yi Zhang 1 2,  Tao Wang 1 2,  Li-Min Hu 1,  Li-Feng Han 1 2
Affiliations

Affiliations

  • 1 a Tianjin State Key Laboratory of Modern Chinese Medicine , Tianjin University of Traditional Chinese Medicine , Tianjin , China.
  • 2 b Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine , Tianjin University of Traditional Chinese Medicine , Tianjin , China.
PMID: 29172686 DOI: 10.1080/14786419.2017.1405410
Abstract

Phytochemical study on the leaves of Epimedium brevicornu finally led to the isolation of four prenylated Flavonoids (1-4) and three dihydrophenanthrenes (5-7), of which 1, 2, 5 and 7 were new compounds. The structures of these compounds were established mainly by spectroscopic techniques, including NMR spectroscopy and mass spectrometry. These isolates exhibited the cytotoxic activities against HepG2 cells with the IC50 values of 32.8-87.3 μM.

Keywords

Epimedium brevicornu; HepG2 cells; cytotoxicity; dihydrophenanthrene; prenylated flavonoid.

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