2. Academic Validation
  3. Isoprenylated phenolic compounds with tyrosinase inhibition from Morus nigra

Isoprenylated phenolic compounds with tyrosinase inhibition from Morus nigra

  • J Asian Nat Prod Res. 2018 May;20(5):488-493. doi: 10.1080/10286020.2017.1350653.
Xiao Hu 1 2,  Mei-Hua Yu 1,  Gui-Rui Yan 3,  He-Yao Wang 3,  Ai-Jun Hou 1,  Chun Lei 1
Affiliations

Affiliations

  • 1 a Department of Pharmacognosy , School of Pharmacy, Fudan University , Shanghai 201203 , China.
  • 2 b Innovation Center of Chinese Medicine, China State Institute of Pharmaceutical Industry , Shanghai 201203 , China.
  • 3 c Shanghai Institute of Materia Medica, Chinese Academy of Science , Shanghai 201203 , China.
PMID: 29191050 DOI: 10.1080/10286020.2017.1350653
Abstract

A new isoprenylated sanggenon-type flavanone, nigrasin K (1), together with three known analogs (2-4) and five known Diels-Alder adducts (5-9), were isolated from the twigs of Morus nigra. Their structures were elucidated by spectroscopic methods. Sanggenon M (2), chalcomoracin (5), sorocein H (6), kuwanon J (7), sanggenon C (8), and sanggenon O (9) showed significant inhibitory effects on mushroom Tyrosinase.

Keywords

Moraceae; Morus nigra; isoprenylated phenolic compounds; mushroom tyrosinase; nigrasin K.

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