2. Academic Validation
  3. Paracoccidioidomycosis: Current Perspectives from Brazil

Paracoccidioidomycosis: Current Perspectives from Brazil

  • Open Microbiol J. 2017 Oct 31;11:224-282. doi: 10.2174/1874285801711010224.
Rinaldo Poncio Mendes 1,  Ricardo de Souza Cavalcante 1,  Sílvio Alencar Marques 2,  Mariângela Esther Alencar Marques 3,  James Venturini 4,  Tatiane Fernanda Sylvestre 1,  Anamaria Mello Miranda Paniago 5,  Ana Carla Pereira 6,  Julhiany de Fátima da Silva 1,  Alexandre Todorovic Fabro 7,  Sandra de Moraes Gimenes Bosco 8,  Eduardo Bagagli 8,  Rosane Christine Hahn 9,  Adriele Dandara Levorato 1
Affiliations

Affiliations

  • 1 Department of Tropical Diseases, Faculdade de Medicina de Botucatu - São Paulo State University - UNESP, São Paulo, Brazil.
  • 2 Department of Dermatology, Faculdade de Medicina de Botucatu - São Paulo State University - UNESP, São Paulo, Brazil.
  • 3 Department of Pathology, Faculdade de Medicina de Botucatu - São Paulo State University - UNESP, São Paulo, Brazil.
  • 4 Laboratory of Experimental Immunology, Department of Biological Science, Faculty of Science, São Paulo State University - UNESP, São Paulo, Brazil.
  • 5 Department of Infectious and Parasitic Diseases, Faculdade de Medicina - Federal University of Mato Grosso do Sul - UFMS, Brazil.
  • 6 Instituto Lauro de Souza Lima, São Paulo State, Bauru, Brazil.
  • 7 Unit of Experimental Research, Faculdade de Medicina de Botucatu - São Paulo State University - UNESP, São Paulo, Brazil.
  • 8 Department of Microbiology and Immunology - Instituto de Biociências de Botucatu - São Paulo State University - UNESP, São Paulo, Brazil.
  • 9 Laboratory of Investigation and Mycology, Federal University of Mato Grosso, Faculty of Medicine Cuiabá, Mato Grosso, Brazil.
PMID: 29204222 DOI: 10.2174/1874285801711010224
Abstract

Background: This review article summarizes and updates the knowledge on paracoccidioidomycosis. P lutzii and the cryptic species of P. brasiliensis and their geographical distribution in Latin America, explaining the difficulties observed in the serological diagnosis.

Objectives: Emphasis has been placed on some genetic factors as predisposing condition for paracoccidioidomycosis. Veterinary aspects were focused, showing the wide distribution of Infection among Animals. The cell-mediated immunity was better characterized, incorporating the recent findings.

Methods: Serological methods for diagnosis were also compared for their parameters of accuracy, including the analysis of relapse.

Results: Clinical forms have been better classified in order to include the pictures less frequently observesiod.

Conclusion: Itraconazole and the trimethoprim-sulfamethoxazole combination was compared regarding efficacy, effectiveness and safety, demonstrating that azole should be the first choice in the treatment of paracoccidioidomycosis.

Keywords

Antifungal compounds; Endemic mycosis; Paracoccidioides brasiliensis; Paracoccidioides lutzii; Paracoccidioidmycosis; Systemic mycosis.

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