2. Academic Validation
  3. Isolation and characterization of new antibiotics resorcinomycins A and B

Isolation and characterization of new antibiotics resorcinomycins A and B

  • J Antibiot (Tokyo). 1989 Jan;42(1):1-6. doi: 10.7164/antibiotics.42.1.
E Kondo 1,  T Katayama,  Y Kawamura,  Y Yasuda,  K Matsumoto,  K Ishii,  T Tanimoto,  H Hinoo,  T Kato,  H Kyotani
Affiliations

Affiliation

  • 1 Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
PMID: 2921214 DOI: 10.7164/antibiotics.42.1
Abstract

New Antibiotics, resorcinomycins A and B, were isolated from the culture broth of a streptomycete strain identified as Streptoverticillium roseoverticillatum. The Antibiotics are water-soluble amphoteric substances, positive to SAKAGUCHI'S reagent. The molecular formulas C14H20N4O5 and C13H18N4O5 for A and B were indicated by elemental analysis and secondary ion MS. The structures of these Antibiotics were determined by 1H and 13C NMR spectrometry and some chemical evidences to be N-[(S)-alpha-guanidino-3,5-dihydroxy-4-isopropylphenylacetyl]glyci ne and N-[(S)-alpha-guanidino-3,5-dihydroxy-4-ethylphenylacetyl]-glycine, respectively.

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