2. Academic Validation
  3. Synthesis, optical properties and cytotoxicity of meso-heteroatom substituted IR-786 analogs

Synthesis, optical properties and cytotoxicity of meso-heteroatom substituted IR-786 analogs

  • Bioorg Med Chem Lett. 2018 Feb 1;28(3):509-514. doi: 10.1016/j.bmcl.2017.12.001.
Xiaozhong Ma 1,  Matthew Laramie 1,  Maged Henary 2
Affiliations

Affiliations

  • 1 Department of Chemistry, Georgia State University, United States.
  • 2 Department of Chemistry, Georgia State University, United States; Center for Diagnostics and Therapeutics, Petit Science Center, 100 Piedmont Ave SE, Atlanta, GA 30303, United States. Electronic address: mhenary1@gsu.edu.
PMID: 29249562 DOI: 10.1016/j.bmcl.2017.12.001
Abstract

Eight near-infrared heptamethine cyanines have been successfully synthesized based on IR 786 with oxygen, sulfur and amine moieties at the central position. These dyes show diverse optical properties resulting from different substitutions. Particularly, the heptamethine dyes with amine moieties have larger Stokes shifts and higher quantum yields of fluorescence. We also investigated these dyes for tumor cell cytotoxicity using cell viability and in vitro proliferation assays. Two of the compounds showed high cytotoxicity against PC-3 Cancer cells.

Keywords

Cytotoxicity; Heptamethine; IR 786; NIR; Optical properties.

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