2. Academic Validation
  3. Emimycin and its nucleoside derivatives: Synthesis and antiviral activity

Emimycin and its nucleoside derivatives: Synthesis and antiviral activity

  • Eur J Med Chem. 2018 Jan 20:144:93-103. doi: 10.1016/j.ejmech.2017.12.018.
Elzbieta Plebanek 1,  Eveline Lescrinier 1,  Graciela Andrei 2,  Robert Snoeck 2,  Piet Herdewijn 1,  Steven De Jonghe 3
Affiliations

Affiliations

  • 1 Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven, Herestraat 49 - bus 1041, 3000 Leuven, Belgium.
  • 2 Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Herestraat 49 - bus 1043, 3000 Leuven, Belgium.
  • 3 Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Herestraat 49 - bus 1043, 3000 Leuven, Belgium. Electronic address: steven.dejonghe@kuleuven.be.
PMID: 29268134 DOI: 10.1016/j.ejmech.2017.12.018
Abstract

The synthesis of emimycin, 5-substituted emimycin analogues and the corresponding ribo- and 2'-deoxyribonucleoside derivatives is described. Emimycin, its 5-substituted congeners and the ribonucleoside derivatives are completely devoid of Antiviral activity against RNA viruses. In contrast, some of the 2'-deoxyribosyl emimycin derivatives are potent inhibitors of the replication of herpes simplex virus-1 and varicella-zoster virus, lacking cytotoxicity.

Keywords

Antiviral; Emimycin; Nucleoside; Pyrazine.

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