Sinopestalotiollides A-D, cytotoxic diphenyl ether derivatives from plant endophytic fungus Pestalotiopsis palmarum

Bioorg Med Chem Lett. 2018 Feb 1;28(3):515-518. doi: 10.1016/j.bmcl.2017.11.044.

Jian Xiao ¹, Jia-Yao Hu ², Hao-Dong Sun ³, Xiang Zhao ², Wan-Tong Zhong ², Dong-Zhu Duan ², Le Wang ², Xiao-Ling Wang ⁴

Affiliations

1 Shaanxi Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji 721013, Shaanxi, PR China. Electronic address: xjxs163@126.com.
2 Shaanxi Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji 721013, Shaanxi, PR China.
3 Baoji Middle School, Baoji 721013, Shaanxi, PR China.
4 Shaanxi Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji 721013, Shaanxi, PR China. Electronic address: xlwangwang@163.com.

PMID: 29295796 DOI: 10.1016/j.bmcl.2017.11.044

Abstract

Four new diphenyl ether derivatives, sinopestalotiollides A-D (1-4), one new natural α-pyrone product (11), as well as twelve known compounds (5-1 7), were obtained from the ethyl acetate extract of the endophytic fungus Pestalotiopsis palmarum isolated from the leaves of medicinal plant Sinomenium acutum (Thunb.) Rehd et Wils. The structures were elucidated by HR-ESI-MS and NMR spectrometry data. Bioassay experiments revealed that compounds 1-4 and 11 exhibited strong to weak cytotoxicities against three human tumor cell lines Hela, HCT116 and A549.

Keywords

Cytotoxic activity; Diphenyl ether derivatives; Pestalotiopsis palmarum.

Name
Email *

	Sorry, but the email address you supplied was invalid.