Glycogen synthase kinase-3 and its inhibitors: Potential target for various therapeutic conditions

Eur J Med Chem. 2018 Jan 20:144:843-858. doi: 10.1016/j.ejmech.2017.11.103.

A Prasanth Saraswati ¹, S M Ali Hussaini ², Namballa Hari Krishna ³, Bathini Nagendra Babu ¹, Ahmed Kamal ⁴

Affiliations

1 Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500 037, India.
2 Medicinal Chemistry & Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India.
3 Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500 037, India; Medicinal Chemistry & Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India.
4 Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500 037, India; Medicinal Chemistry & Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India; School Pharmaceutical Education and Research (SPER), Jamia Hamdard, New Delhi 110062, India. Electronic address: ahmedkamal@iict.res.in.

PMID: 29306837 DOI: 10.1016/j.ejmech.2017.11.103

Abstract

Glycogen Synthase Kinase-3 (GSK-3) is a serine/threonine kinase which is ubiquitously expressed and is regarded as a regulator for various cellular events and signalling pathways. It exists in two isoforms, GSK-3α and GSK-3β and can phosphorylate a wide range of substrates. Aberrancy in the GSK-3 activity can lead to various diseases like Alzheimer's, diabetes, Cancer, neurodegeneration etc., rendering it an attractive target to develop potent and specific inhibitors. The present review focuses on the recent developments in the area of GSK-3 inhibitors and also enlightens its therapeutic applicability in various disease conditions.

Keywords

Alzheimer's; Cancer; Diabetes; GSK-3 inhibitors; Neurodegeneration.

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