2. Academic Validation
  3. Dimeric quinacrines as chemical tools to identify PPT1, a new regulator of autophagy in cancer cells

Dimeric quinacrines as chemical tools to identify PPT1, a new regulator of autophagy in cancer cells

  • Mol Cell Oncol. 2017 Nov 30;5(1):e1395504. doi: 10.1080/23723556.2017.1395504.
Michael C Nicastri 1,  Vito W Rebecca 2,  Ravi K Amaravadi 2 3,  Jeffrey D Winkler 1 3
Affiliations

Affiliations

  • 1 Department of Chemistry; University of Pennsylvania, Philadelphia, PA.
  • 2 Department of Medicine; University of Pennsylvania, Philadelphia, PA.
  • 3 Abramson Cancer Center; University of Pennsylvania, Philadelphia, PA.
PMID: 29404393 DOI: 10.1080/23723556.2017.1395504
Abstract

DQ661 is a novel dimeric quinacrine that affects multiple lysosomal functions (Autophagy and macropinocytosis) and mTORC1 (mechanistic target of rapamycin) activity by specifically targeting protein-palmitoyl thioesterase 1 (PPT1). DQ661 has in vivo activity in immunocompetent mouse models of Cancer, and constitutes a new tool compound for the study of lysosomal function in Cancer and therapeutic resistance.

Keywords

PPT1; autophagy; lysosome; mTOR; macropinocytosis.

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