2. Academic Validation
  3. Oxyntomodulin: Actions and role in diabetes

Oxyntomodulin: Actions and role in diabetes

  • Peptides. 2018 Feb:100:48-53. doi: 10.1016/j.peptides.2017.09.018.
Jens J Holst 1,  Nicolai J Wewer Albrechtsen 2,  Maria Buur Nordskov Gabe 2,  Mette Marie Rosenkilde 2
Affiliations

Affiliations

  • 1 Department of Biomedical Sciences & Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: jjholst@sund.ku.dk.
  • 2 Department of Biomedical Sciences & Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
PMID: 29412831 DOI: 10.1016/j.peptides.2017.09.018
Abstract

Oxyntomodulin is a product of the glucagon precursor, proglucagon, produced and released from the endocrine L-cells of the gut after enzymatic processing by the precursor prohormone convertase 1/3. It corresponds to the proglucagon sequence 33-69 and thus contains the entire glucagon sequence plus a C-terminal octapeptide, comprising in total 37 Amino acids. As might have been expected, it has glucagon-like bioactivity, but also and more surprisingly also activates the receptor for GLP-1. This has given the molecule an interesting status as a glucagon-GLP-1 co-agonist, which is currently attracting considerable interest for its potential in the treatment of diabetes and obesity. Here, we provide an update on oxyntomodulin with a focus on its potential role in metabolic diseases.

Keywords

Diabetes; Oxyntomodulin; Proglucagon.

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