Microporenic Acids A-G, Biofilm Inhibitors, and Antimicrobial Agents from the Basidiomycete Microporus Species

J Nat Prod. 2018 Apr 27;81(4):778-784. doi: 10.1021/acs.jnatprod.7b00764.

Clara Chepkirui ¹, Kamila T Yuyama ², Lucy A Wanga ³, Cony Decock ⁴, Josphat C Matasyoh ⁵, Wolf-Rainer Abraham ², Marc Stadler ¹

Affiliations

1 Department of Microbial Drugs , Helmholtz Centre for Infection Research; and German Centre for Infection Research (DZIF) , Partner Site Hannover/Braunschweig, Inhoffenstrasse 7 , 38124 Braunschweig , Germany.
2 Department of Chemical Microbiology , Helmholtz Centre for Infection Research , Inhoffenstrasse 7 , 38124 Braunschweig , Germany.
3 Department of Biochemistry, Faculty of Sciences , Egerton University , P.O. Box 536, 20115 , Njoro , Kenya.
4 Mycothéque de l' Universite Catholique de Louvain (BCCM/MUCL) , Place Croix du Sud 3 , B-1348 Louvain-la-Neuve , Belgium.
5 Department of Chemistry, Faculty of Sciences , Egerton University , P.O. Box 536, 20115 , Njoro , Kenya.

PMID: 29489350 DOI: 10.1021/acs.jnatprod.7b00764

Abstract

The need for effective compounds to combat antimicrobial resistance and biofilms which play important roles in human infections continues to pose a major health challenge. Seven previously undescribed acyclic diterpenes linked to isocitric acid by an ether linkage, microporenic acids A-G (1-7), were isolated from the cultures of a hitherto undescribed species of the genus Microporus (Polyporales, Basidiomycota) originating from Kenya's Kakamega forest. Microporenic acids D and E (4 and 5) showed antimicrobial activity against a panel of Gram positive bacteria and a yeast, Candida tenuis. Moreover, microporenic acids A and B (1 and 2) demonstrated dose-dependent inhibition of biofilm formation by Staphylococcus aureus. Compound 1 further showed significant activity against Candida albicans and Staphylococcus aureus preformed biofilms.

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