2. Academic Validation
  3. Selective inhibition of leukemia-associated SHP2E69K mutant by the allosteric SHP2 inhibitor SHP099

Selective inhibition of leukemia-associated SHP2E69K mutant by the allosteric SHP2 inhibitor SHP099

  • Leukemia. 2018 May;32(5):1246-1249. doi: 10.1038/s41375-018-0020-5.
X Sun 1,  Y Ren 2,  S Gunawan 3,  P Teng 4,  Z Chen 2,  H R Lawrence 3,  J Cai 4,  N J Lawrence 3,  J Wu 5 6 7
Affiliations

Affiliations

  • 1 Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
  • 2 Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
  • 3 Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
  • 4 Department of Chemistry, University of South Florida, Tampa, FL, USA.
  • 5 Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. jie-wu@ouhsc.edu.
  • 6 Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. jie-wu@ouhsc.edu.
  • 7 Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. jie-wu@ouhsc.edu.
PMID: 29568093 DOI: 10.1038/s41375-018-0020-5
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