2. Academic Validation
  3. MARCH2 is upregulated in HIV-1 infection and inhibits HIV-1 production through envelope protein translocation or degradation

MARCH2 is upregulated in HIV-1 infection and inhibits HIV-1 production through envelope protein translocation or degradation

  • Virology. 2018 May;518:293-300. doi: 10.1016/j.virol.2018.02.003.
You Zhang 1,  Jing Lu 1,  Xinqi Liu 2
Affiliations

Affiliations

  • 1 State Key Laboratory of Medicinal Chemical Biology, Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071, China.
  • 2 State Key Laboratory of Medicinal Chemical Biology, Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071, China. Electronic address: liu2008@nankai.edu.cn.
PMID: 29573664 DOI: 10.1016/j.virol.2018.02.003
Abstract

MARCH2 is one of the MARCH family E3 Ligases, which contains eleven members that play pivotal roles in controlling the turn-over of membrane proteins, such as MHC class I, MHC class II, and cell surface receptors. In this study, we found the expression of MARCH2 to be upregulated upon HIV-1 Infection. MARCH2 inhibits the production and Infection of HIV-1 through Ligase activity-dependent envelope protein degradation and/or intracellular retention, a mechanism shared by MARCH8 that also leads to the inhibition of HIV-1 Infection. Nevertheless, unlike MARCH8 and Other MARCH proteins whose transcription levels are unrelated to viral Infection, the expression level of MARCH2 is markedly upregulated upon HIV-1 Infection, conferring MARCH2 a unique role in monitoring and regulating the HIV-1 infection-associated process.

Keywords

Envelope proteins; HIV-1; MARCH2; Viral inhibition.

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