2. Academic Validation
  3. Synthetic analogues of durantoside I from Citharexylum spinosum L. and their cytotoxic activity

Synthetic analogues of durantoside I from Citharexylum spinosum L. and their cytotoxic activity

  • Bioorg Med Chem Lett. 2018 May 15;28(9):1558-1561. doi: 10.1016/j.bmcl.2018.03.068.
Jutamas Apisornopas 1,  Patamawadee Silalai 1,  Teerapich Kasemsuk 2,  Anan Athipornchai 1,  Uthaiwan Sirion 1,  Kanoknetr Suksen 3,  Pawinee Piyachaturawat 3,  Apichart Suksamrarn 4,  Rungnapha Saeeng 5
Affiliations

Affiliations

  • 1 Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Burapha University, Chonburi 20131, Thailand.
  • 2 Department of Chemistry, Faculty of Science and Technology, Rambhai Barni Rajabhat University, Chanthaburi 22000, Thailand.
  • 3 Department of Physiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
  • 4 Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand.
  • 5 Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Burapha University, Chonburi 20131, Thailand. Electronic address: rungnaph@buu.ac.th.
PMID: 29606574 DOI: 10.1016/j.bmcl.2018.03.068
Abstract

New iridoid glycoside derivatives from durantoside I, the latter from the dried flowers and leaves of Citharexylum spinosum, were synthesized by variously modifying a sugar moiety by silylation or acetylation and/or removal of cinnamate group at C-7 position and subsequent screening for comparative cytotoxicity against several Cancer cell lines. Addition of alkylsilane to durantoside I and removal of cinnamate group were most effective in improving cytotoxicity.

Keywords

Citharexylum spinosum L.; Cytotoxic activity; Durantoside I; Iridoid glycoside.

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