2. Academic Validation
  3. Synthesis, molecular modeling studies and evaluation of antifungal activity of a novel series of thiazole derivatives

Synthesis, molecular modeling studies and evaluation of antifungal activity of a novel series of thiazole derivatives

  • Eur J Med Chem. 2018 May 10:151:248-260. doi: 10.1016/j.ejmech.2018.03.083.
Cleudiomar Inácio Lino 1,  Igor Gonçalves de Souza 1,  Beatriz Martins Borelli 2,  Thelma Tirone Silvério Matos 2,  Iasmin Natália Santos Teixeira 1,  Jonas Pereira Ramos 3,  Elaine Maria de Souza Fagundes 3,  Philipe de Oliveira Fernandes 4,  Vinícius Gonçalves Maltarollo 1,  Susana Johann 2,  Renata Barbosa de Oliveira 5
Affiliations

Affiliations

  • 1 Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • 2 Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • 3 Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • 4 Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • 5 Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address: renatabo.ufmg@gmail.com.
PMID: 29626797 DOI: 10.1016/j.ejmech.2018.03.083
Abstract

In the search for new Antifungal agents, a novel series of fifteen hydrazine-thiazole derivatives was synthesized and assayed in vitro against six clinically important Candida and Cryptococcus species and Paracoccidioides brasiliensis. Eight compounds showed promising Antifungal activity with minimum inhibitory concentration (MIC) values ranging from 0.45 to 31.2 μM, some of them being equally or more active than the drug fluconazole and amphotericin B. Active compounds were additionally tested for toxicity against human embryonic kidney (HEK-293) cells and none of them exhibited significant cytotoxicity, indicating high selectivity. Molecular modeling studies results corroborated experimental SAR results, suggesting their use in the design of new Antifungal agents.

Keywords

Antifungal agents; Hydrazine-thiazoles; QSAR.

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