2. Academic Validation
  3. Anticomplement compounds from Polygonum chinense

Anticomplement compounds from Polygonum chinense

  • Bioorg Med Chem Lett. 2018 May 15;28(9):1495-1500. doi: 10.1016/j.bmcl.2018.03.079.
Hao-Chuan Zheng 1,  Yan Lu 2,  Dao-Feng Chen 3
Affiliations

Affiliations

  • 1 State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China; Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, China.
  • 2 Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, China.
  • 3 State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China; Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, China. Electronic address: dfchen@shmu.edu.cn.
PMID: 29631958 DOI: 10.1016/j.bmcl.2018.03.079
Abstract

Five new compounds including two phenyldilactones (1, 2), two Coumarins (3, 4) and a dimer of N-E-feruloyl tyramine (5) together with twenty-three known compounds (6-28) were isolated from a medicinal plant Polygonum chinense. The structures of the new compounds were established by detailed spectral analysis. The absolute configurations of 1 and 5 were elucidated by Mosher's method, Mo2(OAc)4-induced electronic circular dichroism (ECD) data, and ECD calculation. All the compounds were found to show potent anticomplement activity with CH50 and AP50 values ranging from 0.18 to 1.45 mM, and 0.26 to 2.80 mM, respectively. Phenyldilactones and phenylpropionic tyramines were firstly reported as anticomplement agents. The targets of compounds 1, 3, 5 and 10 in complement activation cascade were identified as well.

Keywords

Anticomplement; Phenyldilactones; Phenylpropionic tyramines; Polygonum chinense; Traditional Chinese medicines.

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