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  3. Study on Liposomal Encapsulation of New Bodipy Sensitizers for Photodynamic Therapy

Study on Liposomal Encapsulation of New Bodipy Sensitizers for Photodynamic Therapy

  • ACS Med Chem Lett. 2018 Feb 4;9(4):323-327. doi: 10.1021/acsmedchemlett.7b00490.
Thumuganti Gayathri 1 2,  A Vijayalakshmi 3,  Sreejith Mangalath 4,  Joshy Joseph 4,  N Madhusudhana Rao 3,  Surya Prakash Singh 1 2
Affiliations

Affiliations

  • 1 Polymers and Functional Materials Division, CSIR-Indian Institute of Chemical Technology, Uppal road, Tarnaka, Hyderabad-500007, India.
  • 2 Academy of Scientific and Innovative Research, Uttar Pradesh-201002, India.
  • 3 CSIR-Centre for Cellular & Molecular Biology, Hyderabad-500007, India.
  • 4 CSIR-National Institute for Interdisciplinary Science and Technology, Thiruvananthapuram, Kerala 695019, India.
PMID: 29670694 DOI: 10.1021/acsmedchemlett.7b00490
Abstract

We report a series of four efficient photosensitizers (PSs) based on a Bodipy core for photodynamic therapy (PDT). In the absence of hydrophilic functional groups, these PSs have been encapsulated in liposomes and examined for photocytotoxicity against human ovarian carcinoma cell line (SK-OV-3). The IC50 values obtained are as low as 0.350 μM, which compete with the classical photosensitizer chlorine E6 (IC50 = 0.39 μM) under similar experimental conditions.

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