2. Academic Validation
  3. Inhibition of Rabies Virus by 1,2,3,4,6-Penta- O-galloyl-β-d-Glucose Involves mTOR-Dependent Autophagy

Inhibition of Rabies Virus by 1,2,3,4,6-Penta- O-galloyl-β-d-Glucose Involves mTOR-Dependent Autophagy

  • Viruses. 2018 Apr 17;10(4):201. doi: 10.3390/v10040201.
Zhongzhong Tu 1,  Wenjie Gong 2,  Yan Zhang 3,  Ye Feng 4,  Yan Liu 5,  Changchun Tu 6
Affiliations

Affiliations

  • 1 Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Jilin 130122, China. tudong890901@163.com.
  • 2 Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Jilin 130122, China. gwj020406@163.com.
  • 3 Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Jilin 130122, China. zhangyan.jl@163.com.
  • 4 Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Jilin 130122, China. fengye621@126.com.
  • 5 Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Jilin 130122, China. liu820512@163.com.
  • 6 Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Jilin 130122, China. changchun_tu@hotmail.com.
PMID: 29673174 DOI: 10.3390/v10040201
Abstract

The compound 1,2,3,4,6-penta-O-galloyl-β-d-glucose (PGG), a gallotannin present in various Plants such as Rhus chinensis Mill and Paeonia suffruticosa, has a broad spectrum of Antiviral effects. The present study investigated its potency against Infection of mice with rabies virus (RABV). Results demonstrated that PGG strongly inhibited virus titers (50-fold), viral mRNA expression (up to 90%), and protein synthesis in vitro. Importantly, we found that PGG not only suppressed viral adsorption and entry, but also directly inactivated RABV through suppression of Autophagy by mediating activation of the mTOR-dependent Autophagy signaling pathway. In vivo, PGG (10 mg/kg) alleviated the clinical symptoms and reduced the mortality of infected mice by 27.3%. Collectively, our results indicate that PGG has potent anti-RABV effect, and merits further investigation as an anti-RABV drug.

Keywords

CVS-11; IPS; PGG; RABV; antiviral.

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