Synthesis of some novel dimethine, bis-dimethine cyanine dyes and octacosamethine cyanine dyes endowed with promising biological potency against (HepG2), (Hela), (MCF-7), (MIA), (SN12C) and (H358) cell lines

Bioorg Med Chem Lett. 2018 Jun 1;28(10):1747-1752. doi: 10.1016/j.bmcl.2018.04.032.

Rasha E El-Mekawy ¹, A A Fadda ²

Affiliations

1 Department of Petrochemicals, Egyptian Petroleum Research Institute, Nasr City, Cairo, Egypt. Electronic address: rashachemistry1@yahoo.com.
2 Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt.

PMID: 29673982 DOI: 10.1016/j.bmcl.2018.04.032

Abstract

Successfully, one step two component synthesis of dimethine cyanine dyes, bis-dimethine cyanine dyes and icosamethine cyanine dyes 2-10via reaction of pyridinium salt 1 with some different aldehydes hope to obtain these compounds with enhanced biological potency as antitumor agents against spontaneous liver (HepG2), cervical (Hela), breast (MCF-7), pancreas (MIA), kidney (SN12C) and lung (H358). The impact of substituted drugs on the tumor cells was reflected by means of structure activity relationship (SAR). Among these dyes, icosamethine cyanine dye 8 recorded an excellent activity toward all the tested cell lines. The newly destined drugs were identified and emphasized by spectroscopy and elemental analyses.

Keywords

Bis-dimethine cyanie dyes; Dimethine cyanine dyes; Liver cancer cell; Octacosamethine cyanine dyes; Porphyrin.

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