2. Academic Validation
  3. Three New Cytotoxic Steroidal Alkaloids from Sarcococca hookeriana

Three New Cytotoxic Steroidal Alkaloids from Sarcococca hookeriana

  • Molecules. 2018 May 15;23(5):1181. doi: 10.3390/molecules23051181.
Kang He 1,  Jinxi Wang 2,  Juan Zou 3,  Jichun Wu 4,  Shaojie Huo 5,  Jiang Du 6
Affiliations

Affiliations

  • 1 The Key Laboratory of Miao Medicine of Guizhou Province, Guiyang College of Traditional Chinese Medicine, Guiyang 550025, Guizhou, China. hekang0851@163.com.
  • 2 The Ethnical Medicine Research Institute of Qian Dong Nan Miao and Dong Autonomous Prefecture, Kaili 556000, Guizhou, China. 15185660328@163.com.
  • 3 The Key Laboratory of Miao Medicine of Guizhou Province, Guiyang College of Traditional Chinese Medicine, Guiyang 550025, Guizhou, China. zoujuan@hotmail.com.
  • 4 The Key Laboratory of Miao Medicine of Guizhou Province, Guiyang College of Traditional Chinese Medicine, Guiyang 550025, Guizhou, China. wujichun2018@sina.com.
  • 5 The Key Laboratory of Miao Medicine of Guizhou Province, Guiyang College of Traditional Chinese Medicine, Guiyang 550025, Guizhou, China. 15038115764@163.com.
  • 6 The Key Laboratory of Miao Medicine of Guizhou Province, Guiyang College of Traditional Chinese Medicine, Guiyang 550025, Guizhou, China. dujang.gz@163.com.
PMID: 29762510 DOI: 10.3390/molecules23051181
Abstract

Three new steroidal Alkaloids with an unusual 3α tigloylamide group, named sarchookloides A⁻C (1⁻3), were isolated along with four known compounds (4⁻7) from the roots of Sarcococca hookeriana. Their structures and relative configuration were elucidated on the basis of spectroscopic methods including MS, UV, IR, 1D, and 2D NMR data. The isolated compounds were evaluated for their cytotoxicity against five human Cancer cell lines: Hela, A549, MCF-7, SW480, and CEM in vitro. All three amide substituted steroidal Alkaloids exhibited significant cytotoxic activities with IC50 values of 1.05⁻31.83 μM.

Keywords

Sarcococca hookeriana; cytotoxicity; sarchookloides A–C; steroidal alkaloid.

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