2. Academic Validation
  3. Three new cyathane diterpenes with neurotrophic activity from the liquid cultures of Hericium erinaceus

Three new cyathane diterpenes with neurotrophic activity from the liquid cultures of Hericium erinaceus

  • J Antibiot (Tokyo). 2018 Sep;71(9):818-821. doi: 10.1038/s41429-018-0065-8.
Yuting Zhang 1 2,  Li Liu 1 2,  Li Bao 3,  Yanlong Yang 1,  Ke Ma 1 2,  Hongwei Liu 4 5
Affiliations

Affiliations

  • 1 State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, No. 1 Beichenxi Road, Chaoyang District, Beijing, 100101, People's Republic of China.
  • 2 Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
  • 3 State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, No. 1 Beichenxi Road, Chaoyang District, Beijing, 100101, People's Republic of China. baol@im.ac.cn.
  • 4 State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, No. 1 Beichenxi Road, Chaoyang District, Beijing, 100101, People's Republic of China. liuhw@im.ac.cn.
  • 5 Savaid Medical School, University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China. liuhw@im.ac.cn.
PMID: 29780164 DOI: 10.1038/s41429-018-0065-8
Abstract

Three new cyathane diterpenes erinacines T-V (1-3), and two known cyathane diterpenes erinacine A (4) and erinacine P (5) were isolated from the liquid cultures of Hericium erinaceus. The structures of 1-3 were determined by extensive spectroscopic analysis. All isolated compounds were evaluated for the cytotoxicity, and neurite-promoting activities using PC12 cell line. Compounds 1-3, and 5 exhibited pronounced neurite outgrowth-promoting effects on PC12 cells in the range of 2.5-10 μM. Compound 4 showed weak cytotoxicity against PC12 cells with IC50 of 73.7 μM.

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