Cytotoxic and Antibacterial Eremophilane Sesquiterpenes from the Marine-Derived Fungus Cochliobolus lunatus SCSIO41401

J Nat Prod. 2018 Jun 22;81(6):1405-1410. doi: 10.1021/acs.jnatprod.8b00015.

Wei Fang ¹ ², Jianjiao Wang ², Junfeng Wang ², Liqiao Shi ¹, Kunlong Li ², Xiuping Lin ², Yong Min ¹, Bin Yang ², Lan Tang ³, Yonghong Liu ², Xuefeng Zhou ²

Affiliations

1 Hubei Biopesticide Engineering Research Center , Hubei Academy of Agricultural Science , Wuhan 430064 , China.
2 CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology , Chinese Academy of Sciences , Guangzhou 510301 , China.
3 Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences , Southern Medical University , Guangzhou 510515 , China.

PMID: 29786436 DOI: 10.1021/acs.jnatprod.8b00015

Abstract

Three new eremophilane Sesquiterpenes, dendryphiellins H-J (1-3), and three new phthalide Natural Products (4-6) were isolated from the marine-derived fungus Cochliobolus lunatus SCSIO41401. Their structures including absolute configurations were determined by spectroscopic and calculated ECD analyses. Dendryphiellin I (2) showed cytotoxic and Antibacterial activities against five Cancer cell lines (IC₅₀ 1.4 to 4.3 μM) and three Bacterial species (MIC 1.5 to 13 μg/mL), respectively. Dendryphiellin J (3), a rare naturally occurring aldoxime analogue, displayed cytotoxicities against ACHN and HepG-2 cells with IC₅₀ values of 3.1 and 5.9 μM, respectively. Further studies indicated that 3 induced Apoptosis in ACHN cells in a dose- and time-dependent manner.

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