2. Academic Validation
  3. Gö6983 attenuates titanium particle-induced osteolysis and RANKL mediated osteoclastogenesis through the suppression of NFκB/JNK/p38 pathways

Gö6983 attenuates titanium particle-induced osteolysis and RANKL mediated osteoclastogenesis through the suppression of NFκB/JNK/p38 pathways

  • Biochem Biophys Res Commun. 2018 Sep 3;503(1):62-70. doi: 10.1016/j.bbrc.2018.05.177.
Wenyu Feng 1,  Jia Li 2,  Shijie Liao 1,  Shiting Ma 1,  Feicui Li 3,  Chaoyi Zhong 4,  Guodong Li 4,  Yan Wei 2,  Huading Huang 5,  Qingjun Wei 6,  Jun Yao 7,  Yun Liu 8
Affiliations

Affiliations

  • 1 Departments of Orthopedics, The First Affliated Hospital of Guangxi Medical University, Nanning, Guangxi, China; Research Centre for Regenerative Medicine, Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Nanning, Guangxi, China.
  • 2 Departments of Pathology, The First Affliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
  • 3 Departments of General Medicine, The First Affliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
  • 4 Research Centre for Regenerative Medicine, Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Nanning, Guangxi, China.
  • 5 Departments of Cardiothoracic Surgery, The First Affliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
  • 6 Departments of Orthopedics, The First Affliated Hospital of Guangxi Medical University, Nanning, Guangxi, China; Research Centre for Regenerative Medicine, Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Nanning, Guangxi, China. Electronic address: weiqingjungxnn@163.com.
  • 7 Departments of Orthopedics, The First Affliated Hospital of Guangxi Medical University, Nanning, Guangxi, China; Research Centre for Regenerative Medicine, Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Nanning, Guangxi, China. Electronic address: yaojun800524@126.com.
  • 8 Departments of Orthopedics, The First Affliated Hospital of Guangxi Medical University, Nanning, Guangxi, China; Research Centre for Regenerative Medicine, Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Nanning, Guangxi, China. Electronic address: 275207660@qq.com.
PMID: 29856998 DOI: 10.1016/j.bbrc.2018.05.177
Abstract

Osteoclast activation by wear particles has caused major difficulties for surgeons. Wear particles are the main causes of aseptic prosthetic loosening. Gö6983, a protein kinase C inhibitor, inhibits five subtypes of protein kinase C family members. Here, we found that Gö6983 had an obviously inhibitory effect on wear-particles-induced osteolysis in vivo. In vitro, Gö6983 inhibited RANKL-stimulated osteoclast formation and function by inhibiting the RANKL-stimulated nuclear factor-κB/JNK/p38 signaling pathway. We also observed that Go6983 had no effect on the differentiation of osteoblasts and osteoblast-associated genes expression. According to our data, Gö6983 has potential therapeutic effects for aseptic prosthetic loosening caused by osteoclast activation.

Keywords

Gö6983; Osteoclast; RANKL; Titanium particle.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-13689
    99.32%, PKC Inhibitor
    PKC