2. Academic Validation
  3. Activities of Oxadiazole Antibacterials against Staphylococcus aureus and Other Gram-Positive Bacteria

Activities of Oxadiazole Antibacterials against Staphylococcus aureus and Other Gram-Positive Bacteria

  • Antimicrob Agents Chemother. 2018 Jul 27;62(8):e00453-18. doi: 10.1128/AAC.00453-18.
Sara Ceballos 1,  Choon Kim 2,  Derong Ding 2,  Shahriar Mobashery 2,  Mayland Chang 3,  Carmen Torres 4
Affiliations

Affiliations

  • 1 Area of Biochemistry and Molecular Biology, University of La Rioja, Logroño, Spain.
  • 2 Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA.
  • 3 Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA mchang@nd.edu carmen.torres@unirioja.es.
  • 4 Area of Biochemistry and Molecular Biology, University of La Rioja, Logroño, Spain mchang@nd.edu carmen.torres@unirioja.es.
PMID: 29866865 DOI: 10.1128/AAC.00453-18
Abstract

The activities of four oxadiazoles were investigated with 210 methicillin-resistant Staphylococcus aureus (MRSA) strains. MIC50 and MIC90 values of 1 to 2 and 4 μg/ml, respectively, were observed. We also evaluated the activity of oxadiazole ND-421 against other staphylococci and enterococci and in the presence of oxacillin for selected MRSA strains. The MIC for ND-421 is lowered severalfold in combination with oxacillin, as they synergize. The MIC90 of ND-421 against vancomycin-resistant enterococci is ≤1 μg/ml.

Keywords

Enterococcus; MIC; MRSA; PBPs; Staphylococcus spp.; oxadiazole.

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