1. Academic Validation
  2. Synthesis and biological activities of dithiocarbamates containing 2(5H)-furanone-piperazine

Synthesis and biological activities of dithiocarbamates containing 2(5H)-furanone-piperazine

  • Eur J Med Chem. 2018 Jul 15:155:165-170. doi: 10.1016/j.ejmech.2018.05.056.
Meng-Xue Wei 1 Jiao Zhang 2 Fu-Li Ma 2 Ming Li 2 Jia-Ying Yu 2 Wei Luo 2 Xue-Qiang Li 3
Affiliations

Affiliations

  • 1 State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering, School of Chemistry and Chemical Engineering, Ningxia University, Yinchuan, 750021, China. Electronic address: weimengxue@nxu.edu.cn.
  • 2 State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering, School of Chemistry and Chemical Engineering, Ningxia University, Yinchuan, 750021, China.
  • 3 State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering, School of Chemistry and Chemical Engineering, Ningxia University, Yinchuan, 750021, China. Electronic address: lixq@nxu.edu.cn.
Abstract

A series of new dithiocarbamates containing a 2(5H)-furanone-piperazine group was synthesized. These compounds show good in vitro cytoxic activity. Among them, compound 6c exhibits the best inhibitory activity against HeLa cell lines with an IC50 of 0.06 ± 0.01 μM for 72 h, and it has good inhibitory activity against SMMC-7721 cell lines with an IC50 of 0.006 ± 0.04 μM for 72 h, but the toxicity was lower against LO2 cell lines with an IC50 of 45.76 ± 0.01 μM. The result showed that compound 6c is far more cytoxic towards Cancer cell lines than towards benign cell lines compared with cytosine arabinoside (ARA) in vitro.

Keywords

2(5H)-Furanone; Biological activities; Dithiocarbamates; SMMC-7721 cell lines; Synthesis.

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