2. Academic Validation
  3. Cyclopeptides from the Sponge Stylissa flabelliformis

Cyclopeptides from the Sponge Stylissa flabelliformis

  • J Nat Prod. 2018 Jun 22;81(6):1426-1434. doi: 10.1021/acs.jnatprod.8b00121.
Oh-Seok Kwon 1,  Chang-Kwon Kim 1,  Woong Sub Byun 1,  Joonseok Oh 2 3,  Yeon-Ju Lee 4,  Hyi-Seung Lee 4,  Chung J Sim 5,  Dong-Chan Oh 1,  Sang Kook Lee 1,  Ki-Bong Oh 6,  Jongheon Shin 1
Affiliations

Affiliations

  • 1 Natural Products Research Institute, College of Pharmacy , Seoul National University , San 56-1, Sillim , Gwanak, Seoul 151-742 , Korea.
  • 2 Department of Chemistry , Yale University , New Haven , Connecticut 06520 , United States.
  • 3 Chemical Biology Institute , Yale University , West Haven , Connecticut 06516 , United States.
  • 4 Marine Natural Products Laboratory , Korea Institute of Ocean Science & Technology , P.O. Box 29, Seoul 425-600 , Korea.
  • 5 Department of Biological Science, College of Life Science and Nano Technology , Hannam University , 461-6 Jeonmin , Yuseong, Daejeon 305-811 , Korea.
  • 6 Department of Agricultural Biotechnology, College of Agriculture and Life Science , Seoul National University , San 56-1, Sillim , Gwanak, Seoul 151-921 , Korea.
PMID: 29893558 DOI: 10.1021/acs.jnatprod.8b00121
Abstract

Three new Cyclopeptides, phakellistatins 20-22 (1-3), as well as 10 known Cyclopeptides of the same structural class were isolated from the tropical Sponge Stylissa flabelliformis. By a combination of chemical and spectroscopic methods, the structures of the new compounds were determined to be an epimeric mixture of cycloheptapeptides (1) and two epimeric cyclodecapeptides (2 and 3) related to the phakellistatins. The Cyclopeptides were evaluated for in vitro cytotoxicity against a variety of Cancer cell lines, and compounds 2 and 3 exhibited significant activity.

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