2. Academic Validation
  3. Aplasmomycin and boromycin are specific inhibitors of the futalosine pathway

Aplasmomycin and boromycin are specific inhibitors of the futalosine pathway

  • J Antibiot (Tokyo). 2018 Nov;71(11):968-970. doi: 10.1038/s41429-018-0087-2.
Yohei Shimizu 1,  Yasushi Ogasawara 2,  Atsuko Matsumoto 3,  Tohru Dairi 4
Affiliations

Affiliations

  • 1 Graduate School of Engineering, Hokkaido University, Sapporo, Hokkaido, 060-8628, Japan.
  • 2 Graduate School of Engineering, Hokkaido University, Sapporo, Hokkaido, 060-8628, Japan. yogasawa@eng.hokudai.ac.jp.
  • 3 Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, 108-8641, Japan.
  • 4 Graduate School of Engineering, Hokkaido University, Sapporo, Hokkaido, 060-8628, Japan. dairi@eng.hokudai.ac.jp.
PMID: 30089869 DOI: 10.1038/s41429-018-0087-2
Abstract

We searched for specific inhibitors of the futalosine pathway, non-canonical pathway of menaquinone biosynthesis operating in Helicobacter pylori, from metabolites produced by actinomycetes. Aplasmomycin, a boron-containing macrodiolide, was isolated from Streptomyces sp. K15-0223 as a specific inhibitor of the futalosine pathway. We also showed boromycin, an analog of aplasmomycin, had similar activity.

Figures
Products