2. Academic Validation
  3. Hippocampal sclerosis induced in mice by a Taenia crassiceps metacestode factor

Hippocampal sclerosis induced in mice by a Taenia crassiceps metacestode factor

  • J Helminthol. 2019 Nov;93(6):690-696. doi: 10.1017/S0022149X18000755.
N Zepeda 1,  N Copitin 1,  J L Chávez 2,  F García 3,  F Jaimes-Miranda 3,  R Rincón-Heredia 3,  R Paredes 3,  S Solano 4,  A M Fernández 4,  J L Molinari 1
Affiliations

Affiliations

  • 1 Departamento de Bioquímica y Biología Estructural, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México, C.P. 04510 A.P. 70-242.
  • 2 Departamento de Neurociencia Cognitiva, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México, C.P. 04510 A.P. 70-242.
  • 3 Unidad de Imagenología, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad de México, C.P. 04510 A.P. 70-242.
  • 4 Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, 04510.
PMID: 30136641 DOI: 10.1017/S0022149X18000755
Abstract

An experimental Taenia crassiceps mouse model was used to assess the role of Taenia solium metacestode factor (Fac) in human neurocysticercosis. Intraperitoneal Infection with T. crassiceps metacestodes or subcutaneous inoculation with a T. crassiceps metacestode factor (Fac) produced significant impairment of performance (learning) in the Barnes maze and induced bilateral hippocampal sclerosis in mice. Several staining techniques revealed important cell dispersion, extensive Apoptosis and cell loss in the dentate gyrus, hilus and CA1-CA3 regions of both hippocampi, as well as intense deterioration of the adjacent cortex. An outstanding disruption of its histoarchitecture in the surrounding tissue of all these regions and Apoptosis of the endothelial cells were also observed.

Keywords

Barnes maze; Taenia crassiceps; Taenia solium; apoptosis; hippocampal sclerosis, metacestode factor (Fac); mouse model; neurocysticercosis.

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