2. Academic Validation
  3. New phenoxazinone-related alkaloids from strain Streptomyces sp. KIB-H1318

New phenoxazinone-related alkaloids from strain Streptomyces sp. KIB-H1318

  • J Antibiot (Tokyo). 2018 Nov;71(12):1040-1043. doi: 10.1038/s41429-018-0099-y.
Feng-Xian Yang 1 2,  Guan-Xiong Hou 1,  Jianying Luo 1,  Jing Yang 1,  Yijun Yan 1,  Sheng-Xiong Huang 3
Affiliations

Affiliations

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, CAS Center for Excellence in Molecular Plant Sciences, Kunming Institute of Botany, Chinese Academy of Sciences, 650204, Kunming, China.
  • 2 University of the Chinese Academy of Sciences, 100049, Beijing, China.
  • 3 State Key Laboratory of Phytochemistry and Plant Resources in West China, CAS Center for Excellence in Molecular Plant Sciences, Kunming Institute of Botany, Chinese Academy of Sciences, 650204, Kunming, China. sxhuang@mail.kib.ac.cn.
PMID: 30218038 DOI: 10.1038/s41429-018-0099-y
Abstract

Chemical investigation of a strain Streptomyces sp. KIB-H1318 isolated from soil sample led to the discovery of three new phenoxazinone-related Alkaloids 1-3, as well as two known analogs exfoliazone (4) and viridobrunnine A (5). Their structures were determined on the basis of extensive spectroscopic analysis. The antimicrobial activity and cytotoxicity of the isolates were assayed. Exfoliazone and viridobrunnine A exhibited minor Antibacterial activity against Escherichia coli ATCC 8099, Bacillus subtilis ATCC 6633, and Staphylococcus aureus ATCC 6538. Compound 2 exhibited low cytotoxicity against two human Cancer cell lines HeLa and SW480 with the IC50 values of 36.8 and 37.8 μM, respectively.

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