2. Academic Validation
  3. On the role of the immunoproteasome in transplant rejection

On the role of the immunoproteasome in transplant rejection

  • Immunogenetics. 2019 Mar;71(3):263-271. doi: 10.1007/s00251-018-1084-0.
Michael Basler 1 2,  Jun Li 3 4,  Marcus Groettrup 5 6
Affiliations

Affiliations

  • 1 Division of Immunology, Department of Biology, University of Konstanz, P1101 Universitätsstrasse 10, D-78457, Konstanz, Germany. Michael.Basler@uni-konstanz.de.
  • 2 Biotechnology Institute Thurgau (BITg), University of Konstanz, CH-8280, Kreuzlingen, Switzerland. Michael.Basler@uni-konstanz.de.
  • 3 Division of Immunology, Department of Biology, University of Konstanz, P1101 Universitätsstrasse 10, D-78457, Konstanz, Germany.
  • 4 Department of Urology Oncological Surgery, Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing, 400030, China.
  • 5 Division of Immunology, Department of Biology, University of Konstanz, P1101 Universitätsstrasse 10, D-78457, Konstanz, Germany. Marcus.Groettrup@uni-konstanz.de.
  • 6 Biotechnology Institute Thurgau (BITg), University of Konstanz, CH-8280, Kreuzlingen, Switzerland. Marcus.Groettrup@uni-konstanz.de.
PMID: 30220008 DOI: 10.1007/s00251-018-1084-0
Abstract

The immunoproteasome is expressed in cells of hematopoietic origin and is induced during inflammation by IFN-γ. Targeting the immunoproteasome with selective inhibitors has been shown to be therapeutically effective in pre-clinical models for autoimmune diseases, colitis-associated Cancer formation, and transplantation. Immunoproteasome inhibition prevents activation and proliferation of lymphocytes, lowers MHC class I cell surface expression, reduces the expression of cytokines of activated immune cells, and curtails T helper 1 and 17 cell differentiation. This might explain the in vivo efficacy of immunoproteasome inhibition in different pre-clinical disease models for autoimmunity, Cancer, and transplantation. In this review, we summarize the effect of immunoproteasome inhibition in different animal models for transplantation.

Keywords

Antigen presentation; Antigen processing; Immunoproteasome; Proteasome; Transplantation.

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