2. Academic Validation
  3. Irpeksins A-E, 1,10- seco-Eburicane-Type Triterpenoids from the Medicinal Fungus Irpex lacteus and Their Anti-NO Activity

Irpeksins A-E, 1,10- seco-Eburicane-Type Triterpenoids from the Medicinal Fungus Irpex lacteus and Their Anti-NO Activity

  • J Nat Prod. 2018 Oct 26;81(10):2163-2168. doi: 10.1021/acs.jnatprod.7b00845.
Yang Tang 1 2,  Zhen-Zhu Zhao 1,  Jian-Neng Yao 1 2,  Tao Feng 3,  Zheng-Hui Li 3,  He-Ping Chen 3,  Ji-Kai Liu 3
Affiliations

Affiliations

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , People's Republic of China.
  • 2 University of Chinese Academy of Sciences , Beijing 100049 , People's Republic of China.
  • 3 School of Pharmaceutical Sciences , South-Central University for Nationalities , Wuhan 430074 , People's Republic of China.
PMID: 30296083 DOI: 10.1021/acs.jnatprod.7b00845
Abstract

Five new triterpenoids, irpeksins A-E (1-5), were isolated from fruiting bodies of the medicinal fungus Irpex lacteus. The structures as well as absolute configurations of the new compounds were established via extensive spectroscopic analysis, computational methods, and Cotton effects. Compounds 1-4 are featured by a scaffold of 1,10- seco- and ring B aromatic eburicane (24-methyllanostane), and compound 5 is characterized by a scaffold of 1,10-9,11- diseco- and ring B aromatic eburicane, which represents unprecedented cleavage patterns in the lanostane family. Compounds 1-5 showed significant inhibitory activity against NO production in LPS-activated RAW 264.7 macrophage cells with IC50 values varying from 2.2 to 19.6 μM.

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