2. Academic Validation
  3. Carnosol suppresses patient-derived gastric tumor growth by targeting RSK2

Carnosol suppresses patient-derived gastric tumor growth by targeting RSK2

  • Oncotarget. 2018 Feb 6;9(76):34200-34212. doi: 10.18632/oncotarget.24409.
Li Wang 1,  Yujuan Zhang 1,  Kangdong Liu 1 2 3 4,  Hanyong Chen 5,  Ran Yang 1,  Xiaoli Ma 1 2,  Hong-Gyum Kim 1,  Ann M Bode 5,  Dong Joon Kim 1,  Zigang Dong 1 5
Affiliations

Affiliations

  • 1 China-US (Henan) Hormel Cancer Institute, Henan, China.
  • 2 The Pathophysiology Department, The School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
  • 3 The Affiliated Cancer Hospital, Zhengzhou University, Zhengzhou, Henan, China.
  • 4 The Collaborative Innovation Center of Henan Province for Cancer Chemoprevention, Zhengzhou, China.
  • 5 The Hormel Institute, University of Minnesota, Austin, MN, USA.
PMID: 30344937 DOI: 10.18632/oncotarget.24409
Abstract

Carnosol is a phenolic diterpene that is isolated from rosemary, sage, and oregano. It has been reported to possess anti-oxidant, anti-inflammatory, and anti-cancer properties. However, the molecular mechanism of carnosol's activity against gastric Cancer has not been investigated. Herein, we report that carnosol is an RSK2 Inhibitor that attenuates gastric Cancer growth. Carnosol reduced anchorage-dependent and -independent gastric Cancer growth by inhibiting the RSKs-CREB signaling pathway. The results of in vitro screening and cell-based assays indicated that carnosol represses RSK2 activity and its downstream signaling. Carnosol increased the G2/M phase and decreased S phase cell cycle and also induced Apoptosis through the activation of caspases 9 and 7 and inhibition of Bcl-xL expression. Notably, oral administration of carnosol suppressed patient-derived gastric tumor growth in an in vivo mouse model. Our findings suggest that carnosol is an RSK2 Inhibitor that could be useful for treating gastric Cancer.

Keywords

RSK2; carnosol; gastric cancer; patient-derived tumor xenograft.

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