2. Academic Validation
  3. The Elegance of Sonic Hedgehog: Emerging Novel Functions for a Classic Morphogen

The Elegance of Sonic Hedgehog: Emerging Novel Functions for a Classic Morphogen

  • J Neurosci. 2018 Oct 31;38(44):9338-9345. doi: 10.1523/JNEUROSCI.1662-18.2018.
A Denise R Garcia 1,  Young-Goo Han 2,  Jason W Triplett 3,  W Todd Farmer 4,  Corey C Harwell 5,  Rebecca A Ihrie 6
Affiliations

Affiliations

  • 1 Departments of Biology and Neurobiology and Anatomy, Drexel University, Philadelphia, Pennsylvania, Philadelphia, PA 19146.
  • 2 Department of Developmental Neurobiology, Neurobiology and Brain Tumor Program, St. Jude Children's Research Hospital, Memphis, Tennessee, Memphis, TN 38105.
  • 3 Center for Neuroscience Research, Children's National Medical Center, Departments of Pediatrics and Pharmacology and Physiology, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, Washington, District of Columbia, 20010.
  • 4 Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, Brain Repair and Integrative Neuroscience Program, The Research Institute of the McGill University Health Center, Montreal General Hospital, Montreal, Quebec, Canada, H3G 1A4.
  • 5 Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, MA 02115 corey_harwell@hms.harvard.edu rebecca.ihrie@vanderbilt.edu.
  • 6 Departments of Cell and Developmental Biology and Neurological Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, TN, 37232-6840, and corey_harwell@hms.harvard.edu rebecca.ihrie@vanderbilt.edu.
PMID: 30381425 DOI: 10.1523/JNEUROSCI.1662-18.2018
Abstract

Sonic Hedgehog (SHH) signaling has been most widely known for its role in specifying region and cell-type identity during embryonic morphogenesis. This mini-review accompanies a 2018 SFN mini-symposium that addresses an emerging body of research focused on understanding the diverse roles for Shh signaling in a wide range of contexts in neurodevelopment and, more recently, in the mature CNS. Such research shows that Shh affects the function of brain circuits, including the production and maintenance of diverse cell types and the establishment of wiring specificity. Here, we review these novel and unexpected functions and the unanswered questions regarding the role of SHH and its signaling pathway members in these cases.

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