2. Academic Validation
  3. Spirulina ameliorates aspirin-induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation

Spirulina ameliorates aspirin-induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation

  • Biomed Pharmacother. 2019 Jan:109:314-321. doi: 10.1016/j.biopha.2018.10.118.
Yomna I Mahmoud 1,  Eman A Abd El-Ghffar 2
Affiliations

Affiliations

  • 1 Zoology Department, Faculty of Science, Ain Shams University, Abbassia P.O. Box 11566, Cairo, Egypt. Electronic address: yomna_ia@sci.asu.edu.eg.
  • 2 Zoology Department, Faculty of Science, Ain Shams University, Abbassia P.O. Box 11566, Cairo, Egypt.
PMID: 30396089 DOI: 10.1016/j.biopha.2018.10.118
Abstract

Aspirin is a commonly prescribed non steroidal anti-inflammatory drug, but its prolonged use injures the gastric mucosa. The present study was carried out to evaluate the ameliorative effect of spirulina against aspirin-induced gastric ulcer in albino mice. Gastric ulcer was induced by oral administration of aspirin (500 mg/kg bw). Spirulina (250 and 500 mg/kg bw) was given orally for 3 days after the induction of gastric ulcer. Spirulina ameliorated aspirin-induced gastric ulcer by improving the gross morphology, histology and mucous layer of gastric tissue, augmenting the endogenous enzymatic and non-enzymatic Antioxidants (reduced glutathione, Glutathione Peroxidase, Glutathione Reductase, superoxide dismutase and catalase) and the cytoprotective marker (COX-1), and by alleviating tissue levels of the lipid peroxidation marker (malondialdehyde) and inflammatory mediators (TNF-α, COX-2 and NO). In conclusion, spirulina has a therapeutic potential in aspirin-induced gastric injury by alleviating oxidative stress and inflammation.

Keywords

Aspirin; Gastric ulcer; Immunohistochemistry; Inflammation; Oxidative stress; Spirulina.

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