2. Academic Validation
  3. The Antitumor Activities of Marsdenia tenacissima

The Antitumor Activities of Marsdenia tenacissima

  • Front Oncol. 2018 Oct 23;8:473. doi: 10.3389/fonc.2018.00473.
Xiang Wang 1 2,  Yuanliang Yan 1 2,  Xi Chen 1 2,  Shuangshuang Zeng 1 2,  Long Qian 1 2,  Xinxin Ren 3,  Jie Wei 1 2,  Xue Yang 1 2,  Yangying Zhou 4,  Zhicheng Gong 1 2,  Zhijie Xu 5
Affiliations

Affiliations

  • 1 Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.
  • 2 National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
  • 3 Key Laboratory of Molecular Radiation Oncology of Hunan Province, Center for Molecular Medicine, Xiangya Hospital, Central South University, Changsha, China.
  • 4 Department of Oncology, Xiangya Hospital, Central South University, Changsha, China.
  • 5 Department of Pathology, Xiangya Hospital, Central South University, Changsha, China.
PMID: 30406035 DOI: 10.3389/fonc.2018.00473
Abstract

Marsdenia tenacissima (MT), a traditional Chinese herbal medicine, has long been used for thousands of years to treat asthma, tracheitis, rheumatism, etc. An increasing number of recent studies have focused on the antitumor effects of MT. The effects of MT on Cancer are the result of various activated signaling pathways and inhibiting factors and the high expression levels of regulatory proteins. MT can inhibit different Cancer types including non-small cell lung Cancer (NSCLC), malignant tumors, hepatic carcinoma, and so on. This article mainly focuses on the activities and mechanisms of MT. In addition, the efficacy and toxicity of MT are also discussed. Further studies of MT are required for improved medicinal utilization.

Keywords

Marsdenia tenacissima; antitumor activities; efficacy; malignant tumor; signaling pathways; toxicity.

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