2. Academic Validation
  3. Synthesis and biological evaluation of clovamide analogues with catechol functionality as potent Parkinson's disease agents in vitro and in vivo

Synthesis and biological evaluation of clovamide analogues with catechol functionality as potent Parkinson's disease agents in vitro and in vivo

  • Bioorg Med Chem Lett. 2019 Jan 15;29(2):302-312. doi: 10.1016/j.bmcl.2018.11.030.
Jia-Hao Feng 1,  Xiao-Long Hu 1,  Xian-Yu Lv 1,  Bao-Lin Wang 1,  Jun Lin 1,  Xiao-Qi Zhang 2,  Wen-Cai Ye 2,  Fei Xiong 3,  Hao Wang 4
Affiliations

Affiliations

  • 1 State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
  • 2 Institute of Traditional Chinese Medicine & Natural Products, Jinan University, Guangzhou 510632, People's Republic of China.
  • 3 State Key Laboratory of Bioelectronics, Jiangsu Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, People's Republic of China. Electronic address: xiongfei@seu.edu.cn.
  • 4 State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China. Electronic address: wanghao@cpu.edu.cn.
PMID: 30470490 DOI: 10.1016/j.bmcl.2018.11.030
Keywords

Catechol functionality; Clovamide analogue; Heme oxygenase-1; Oxidative stress; Parkinson’s disease; Pharmacokinetic assessment.

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