2. Academic Validation
  3. Dual-function of triptriolide in podocytes injury: inhibiting of apoptosis and restoring of survival

Dual-function of triptriolide in podocytes injury: inhibiting of apoptosis and restoring of survival

  • Biomed Pharmacother. 2019 Jan:109:1932-1939. doi: 10.1016/j.biopha.2018.11.031.
Yi-Qi Yang 1,  Jian Liang 2,  Xiao-Dong Han 1,  Rui-Min Tian 3,  Xu-Sheng Liu 4,  Wei Mao 4,  Hong-Tao Xu 5,  Bo Liu 6,  Peng Xu 7
Affiliations

Affiliations

  • 1 The Second Clinical Medical College, and Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, 510006, P.R. China.
  • 2 Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, and Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, P.R. China.
  • 3 Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510006, P.R. China.
  • 4 The Second Clinical Medical College, and Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, 510006, P.R. China; Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510006, P.R. China.
  • 5 Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, 201210, P.R. China. Electronic address: xuht@shanghaitech.edu.cn.
  • 6 The Second Clinical Medical College, and Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, 510006, P.R. China; Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510006, P.R. China. Electronic address: doctliu@263.net.
  • 7 The Second Clinical Medical College, and Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, 510006, P.R. China; Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, 510006, P.R. China. Electronic address: xupeng@gzucm.edu.cn.
PMID: 30551448 DOI: 10.1016/j.biopha.2018.11.031
Abstract

Triptriolide (T11) is a natural diterpene diepoxide that derived from Chinese traditional herb medicine (TCHM) Tripterygium wilfordii Hook.F (TWHF). From a structural point of view, T11 is very similar to triptolide (T9), one of the most effectively compounds in TWHF that have already been systematically investigated in the past decades. However, the basic functions and medicinal properties of T11 have not yet been well investigated mainly due to its low abundance in its plant organ. The present study aimed to investigate the protective effects of T11 on puromycin aminonucleoside (PAN) induced apoptotic mouse podocytes and the underlying mechanism. The results showed that T11 had no significant toxicity in podocytes in high dosage, and showed prominent protective effects on PAN induced podocytes injury. Further studies indicated that T11 might exert its protective effects by inhibiting of Apoptosis and restoring of survival in PAN induced podocytes.

Keywords

Apoptosis; PAN; Podocyte; Tripterygium wilfordii; Triptriolide.

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