2. Academic Validation
  3. Pestalotiopisorin B, a new isocoumarin derivative from the mangrove endophytic fungus Pestalotiopsis sp. HHL101

Pestalotiopisorin B, a new isocoumarin derivative from the mangrove endophytic fungus Pestalotiopsis sp. HHL101

  • Nat Prod Res. 2020 Apr;34(7):1002-1007. doi: 10.1080/14786419.2018.1539980.
Zhiyong Xu 1 2,  Xi Wu 1,  Gang Li 1,  Zhao Feng 1,  Jing Xu 1 2
Affiliations

Affiliations

  • 1 Key Laboratory of Tropical Biological Resources of Ministry of Education, College of Material and Chemical Engineering, Hainan University, Haikou, P. R. China.
  • 2 Institute of Tropical Agriculture and Forestry, Hainan University, Haikou, P. R. China.
PMID: 30623682 DOI: 10.1080/14786419.2018.1539980
Abstract

A new isocoumarin derivative pestalotiopisorin B (1), along with six known compounds, (R)-(-)- mellein methyl ether (2), pestalotiopyrone G (3), (R)-mevalonolactone (4), pestalotiollides A-B (5-6) and pestalotiopsol A(7) were isolated from Pestalotiopsis sp., an endophytic fungus obtained from Chinese mangrove plant Rhizophora stylosa. Their structures were elucidated unambiguously by the comprehensive analysis of extensive spectroscopic data. Compound 1 exhibited modest Antibacterial activity against Escherichia coli and Pseudomonas aeruginosa with 12.5 μg/ml, 50 μg/ml, respectively. Compound 4 showed moderate Calcineurin inhibitory activity towards p-nitrophenyl phosphate (IC50 =134.29 ± 5.377 μM).

Keywords

Pestalotiopsis sp.; Rhizophora stylosa; antibacterial activity; calcineurin inhibitory activity; endophytic fungi.

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