Synthetically modified methoxsalen for enhanced cytotoxicity in light and dark reactions

Bioorg Med Chem Lett. 2019 Feb 15;29(4):619-622. doi: 10.1016/j.bmcl.2018.12.048.

Christophe D Guillon ¹, Yi-Hua Jan ², Natalie Foster ³, Joel Ressner ³, Diane E Heck ⁴, Jeffrey D Laskin ², Ned D Heindel ³

Affiliations

1 Department of Chemistry, Lehigh University, Bethlehem, PA 18015 USA. Electronic address: chg3@lehigh.edu.
2 Department of Environmental and Occupational Health, Rutgers University School of Public Health, Piscataway, NJ 08854, USA.
3 Department of Chemistry, Lehigh University, Bethlehem, PA 18015 USA.
4 Department of Environmental Health Science, New York Medical College, Valhalla, NY 10595, USA.

PMID: 30638875 DOI: 10.1016/j.bmcl.2018.12.048

Abstract

Linear furocoumarins, also known as psoralens, are clinically useful photo-activated pharmaceuticals employed to address hyperproliferative skin diseases. Seven diverse cytotoxic pharmacophores have been synthetically attached to 8-methoxypsoralen via a 5-amino functionality. The resulting unique set of compounds was evaluated for dark and light toxicity against PAM212 keratinocytes in culture.

Keywords

8-MOP; 8-Methoxypsoralen; Dark-reaction toxicity; Keratinocytes; PAM212; Phototoxicity.

Name
Email *

	Sorry, but the email address you supplied was invalid.