2. Academic Validation
  3. Daurinoline suppressed the migration and invasion of chemo-resistant human non-small cell lung cancer cells by reversing EMT and Notch-1 and sensitized the cells to Taxol

Daurinoline suppressed the migration and invasion of chemo-resistant human non-small cell lung cancer cells by reversing EMT and Notch-1 and sensitized the cells to Taxol

  • Environ Toxicol Pharmacol. 2019 Feb;66:109-115. doi: 10.1016/j.etap.2018.12.005.
Dan-Dan Li 1,  Xiao-Chun Qin 2,  Yue Yang 2,  Hai-Xiao Chu 2,  Ruo-Lan Li 2,  Ling-Xiang Ma 2,  Huai-Wei Ding 3,  Qing-Chun Zhao 4
Affiliations

Affiliations

  • 1 Department of Pharmacy, General Hospital of Shenyang Military Area Command, Shenyang 110840, China; Department of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • 2 Department of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • 3 Department of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: dinghuaiwei627@163.com.
  • 4 Department of Pharmacy, General Hospital of Shenyang Military Area Command, Shenyang 110840, China; Department of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: zhaoqingchun1967@163.com.
PMID: 30641414 DOI: 10.1016/j.etap.2018.12.005
Abstract

Non-small cell lung Cancer (NSCLC) is one of the most common malignancies, and Taxol is a cornerstone in the treatment. However, taxol-resistance eventually limits the clinical effects and applications. Daurinoline could restore the sensitivity of resistant MCF-7/adr and KBv200 cells. Whereas, the effect of daurinoline on the chemo-resistant NSCLC cells and the mechanism has not been elucidated. In this study, daurinoline was firstly demonstrated that inhibited the proliferation, migration, invasion and EMT phenotype of chemo-resistant NSCLC cells. And these effects were associated with EMT and Notch-1 reversal. Moreover, daurinoline could significantly enhance the anti-tumor effect of Taxol rather than epirubicin, adriamycin and cisplatin. And the reverse fold (RF) value of daurinoline was greater than terfenadine reported before. There are little cytotoxic effects of daurinoline and its derivatives reported by L.W. Fu, et al. (2001). Therefore, daurinoline may be a potential anti-tumor agent or chemosensitizer for chemo-resistant NSCLC patients.

Keywords

Chemosensitization; Daurinoline; EMT; Non-small cell lung cancer.

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