2. Academic Validation
  3. Prenylated Indole Diterpene Alkaloids from a Mine-Soil-Derived Tolypocladium sp

Prenylated Indole Diterpene Alkaloids from a Mine-Soil-Derived Tolypocladium sp

  • J Nat Prod. 2019 Feb 22;82(2):221-231. doi: 10.1021/acs.jnatprod.8b00589.
Lu-Lin Xu 1 2,  Ping Hai 3,  Shuai-Bing Zhang 1,  Jing-Fang Xiao 4,  Yuan Gao 3,  Bing-Ji Ma 5,  Hai-Yan Fu 1,  Ye-Miao Chen 4,  Xiao-Long Yang 1 2
Affiliations

Affiliations

  • 1 School of Pharmaceutical Sciences , South-Central University for Nationalities , Wuhan 430074 , People's Republic of China.
  • 2 Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences , Chongqing University , Chongqing 401331 , People's Republic of China.
  • 3 Department of Chemical Engineering , Yibin University , Yibin 644000 , People's Republic of China.
  • 4 Institute of Pathology and Southwest Cancer Center, Southwest Hospital and Key Laboratory of Tumor Immunopathology of the Ministry of Education of China , Third Military Medical University , Chongqing 400038 , People's Republic of China.
  • 5 Department of Traditional Chinese Medicine , Henan Agricultural University , Wenhua Road 12 , Zhengzhou 450002 , People's Republic of China.
PMID: 30702286 DOI: 10.1021/acs.jnatprod.8b00589
Abstract

Ten new prenylated indole diterpene Alkaloids, tolypocladin A-J (1-10), including four chlorinated metabolites, have been isolated from a culture of a mine-soil-derived fungus, Tolypocladium sp. XL115. The structures and absolute configurations of 1-10 were determined by spectroscopic analysis, ECD calculations, and comparison with known compounds. Compounds 1 and 8 displayed significant antimicrobial activities. In addition, compound 1 also showed weak cytotoxic activity against all tested human Cancer cell lines and suppressed the growth and viability of the patient-derived HCC cells T1224.

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