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  2. MicroRNA-34 family: a potential tumor suppressor and therapeutic candidate in cancer

MicroRNA-34 family: a potential tumor suppressor and therapeutic candidate in cancer

  • J Exp Clin Cancer Res. 2019 Feb 4;38(1):53. doi: 10.1186/s13046-019-1059-5.
Lu Zhang 1 Yi Liao 2 Liling Tang 3
Affiliations

Affiliations

  • 1 Key Laboratory of Biorheological Science and Technology, Ministlry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, China.
  • 2 Department of thoracic surgery, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China. science0528@163.com.
  • 3 Key Laboratory of Biorheological Science and Technology, Ministlry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, China. tangliling@cqu.edu.cn.
Abstract

MicroRNA-34 (miR-34) has been reported to be dysregulated in various human cancers and regarded as a tumor suppressive MicroRNA because of its synergistic effect with the well-known tumor suppressor p53. Along with the application of MRX34, the first tumor-targeted MicroRNA drug which based on miR-34a mimics, on phase I clinical trial (NCT01829971), the significance of miR-34 is increasingly recognized. miR-34 plays a crucial role on repressing tumor progression by involving in epithelial-mesenchymal transition (EMT) via EMT- transcription factors, p53 and some important signal pathways. Not only that, numerous preclinical researches revealed the giant potential of miR-34a on Cancer therapy through diversiform nano-scaled delivery systems. Here, we provide an overview about the function of miR-34 in various cancers and the mechanism of miR-34 in tumor-associated EMT. Furthermore, its potential role as a MicroRNA therapeutic candidate is also discussed. Notwithstanding some obstacles existed, the extensive application prospect of miR-34 on oncotherapy cannot be neglected.

Keywords

Dysregulation; EMT; Oncotherapy; Tumor-suppressive; miR-34.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-119833
    99.1%, miR-34a Modulator