2. Academic Validation
  3. Anti-glycating and anti-oxidant compounds from traditionally used anti-diabetic plant Geigeria alata(DC) Oliv. & Hiern

Anti-glycating and anti-oxidant compounds from traditionally used anti-diabetic plant Geigeria alata(DC) Oliv. & Hiern

  • Nat Prod Res. 2020 Sep;34(17):2456-2464. doi: 10.1080/14786419.2018.1542388.
Eltayeb Fadul 1,  Arsalan Nizamani 2,  Saima Rasheed 2,  Achyut Adhikari 2 3,  Sammer Yousuf 2,  Shahida Parveen 2,  Nezhun Gören 2 4,  Hassan A Alhazmi 5 6,  M Iqbal Choudhary 2 7,  Asaad Khalid 1 6
Affiliations

Affiliations

  • 1 Medical Biochemistry Research Department, Medicinal and Aromatic Plants and Traditional Medicine Research Institute, National Center for Research, Khartoum, Sudan.
  • 2 H. E. J. Research Institute of Chemistry, International Center for Chemicals and Biological Sciences, University of Karachi, Karachi, Pakistan.
  • 3 Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu, Nepal.
  • 4 Department of Molecular Biology and Genetics, Faculty of Science and Arts, Yıldız Technical University, İstanbul, Turkey.
  • 5 Department of Pharmaceutical Chemistry, College of Pharmacy, Jazan University, Jazan, Saudi Arabia.
  • 6 Substance Abuse Research Center, Jazan University, Jazan, Saudi Arabia.
  • 7 Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
PMID: 30732466 DOI: 10.1080/14786419.2018.1542388
Abstract

A new sesquiterpene lactone geigerianoloide (1) and four known Flavonoids axillarin (2), quercetin (3), 3-methoxy-5,7,3',4'-tetrahydroxy-flavone (4) and hispidulin (5) were isolated from Geigeria alata (DC) Oliv. & Hiern. (Asteraceae). Structures were deduced using 1H- and 13C- NMR spectroscopy, mass spectrometry, while the structure of compound 1 was also deduced using X-ray crystallography technique.Geigeria alata is traditionally used for diabetes, therefore compounds were tested for anti-glycation activity, in which compounds 2 and 3 showed potent activities (IC50 values of 246.97 ± 0.83 and 262.37 ± 0.22 µM, respectively) compared to IC50 value 294.50 ± 1.5 µM of rutin. Moreover, compound 4 exhibited a comparable activity to rutin (IC50 = 293.28 ± 1.34 µM). Compound 5 showed a weak activity.Compounds 2, 3, and 4 exhibited potent DPPH radical scavenging activity (IC50 = 0.1 ± 0.00, 0.13 ± 0.00 and 0.15 ± 0.01 µM, respectively). Compounds 2, 3, and 4 demonstrated significant superoxide anion scavenging activity with IC50 values of 0.14 ± 0.001, 0.17 ± 0.00, and 0.11 ± 0.006 µM, respectively.

Keywords

Anti-glycation; Anti-oxidant; Geigeriaalata (DC) Oliv. & Hiern.; Geigerianoloide; axillarin.

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